- 相关推荐
Immunosuppressive Activities of Fucoidan from Laminaria japonica
Effects of fucoidan from Laminaria japonica on 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity (DTH) reaction and the serum levels of IgG, IgM, complement C3 and C4 were investigated in the present study. Results showed that oral administration of fucoidan at dose of 150 and 300 mg/(kg*d) for 9 days before the hapten challenge significantly inhibited 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity reaction; and also inhibited the humoral immunity. Serum C3 and C4 levels were markedly reduced by fucoidan at dose of 150 and 300 mg/kg; and serum IgG and IgM levels were reduced by fucoidan at dose of 300 mg/kg. The inhibitory effects of fucoidan on delayed-type hypersensitivity suggested that it may be potential medication for chronic inflammatory diseases in the future.
作 者： 张全斌 李智恩 周革非 牛锡珍 张虹 作者单位： 张全斌,周革非(Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;The Graduate School of Chinese Academy of Sciences, Beijing 100039, China)李智恩,牛锡珍,张虹(Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China)
刊 名： 中国海洋湖沼学报(英文版) ISTIC SCI 英文刊名： CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 年，卷(期)： 2003 21(4) 分类号： P7 关键词： Laminaria japonica fucoidan delayed-type hypersensitivity humoral immunity【Immunosuppressive Activities of Fuco】相关文章：