双酚A对斑马鱼胚胎的毒性作用

双酚A对斑马鱼胚胎的毒性作用

In order to evaluate the toxicity of the bisphenol A (BPA) on the growth of zebrafish embryos, fertilized eggs were exposed to the concentration of 2.00, 4.00, 6.00, 8.00, 10.00, 15.00, 18.00, 22.00 and 25.00mg/L BPA for72 h at 26± 1 ℃. The results revealed that the sublethal toxicological endpoints induced by BPA were: delayed hatch ＞ blood balk ＞ cyst ＞ altered axial curvature and tail malformation. The median embryo lethal concentration (LC50) after 24 h was 16.36 mg/L. We concluded that the BPA toxicity on zebrafish embryos were caused before 8h exposure and it was not the result of long-term accumulation. Therefore, BPA maybe cause altered gene expression at the early stage of zebrafish embryos. In the further studies, we will use the technology of genetic chips to look for the toxic mechanism of BPA.

作 者： DUAN Zheng-Hua ZHU Lin   作者单位： College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China  刊 名： 水生生物学报  ISTIC PKU 英文刊名： ACTA HYDROBIOLOGICA SINICA  年，卷(期)： 2006 30(6)  分类号： X174  关键词： Bisphenol A   Zebrafish embryos   Toxicity  

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