DNA Cleavage of the Copper(Ⅱ) Comple

DNA Cleavage of the Copper(Ⅱ) Complexes with a Polyamine Ditopic Ligand

A new binuclear complex [Cu2L(OH)](ClO4)3·2H2O has been synthesized and characterized, where L=2,6-bis{[bis-(2-aminoethyl)amino]methyl}-benzene. In the presence of0.5 mmol/L complex at pH 8.10 and 37℃, the complex can efficiently cleavage pBR322 DNA with a rate constant kobs of 1.35 × 10-4 s-1. The cleavage occurred by a non-oxidative mechanism showing activity to be dependent on pH.

作 者： Yi Bin WEI Pin YANG   作者单位： Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan 030006  刊 名： 中国化学快报（英文版）  ISTIC SCI 英文刊名： CHINESE CHEMICAL LETTERS  年，卷(期)： 2005 16(4)  分类号：   关键词： Hydrolytic cleavage   copper complex   binuclear  

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