Synthesis of a New Cobalt (Ⅱ) Comple

Synthesis of a New Cobalt (Ⅱ) Complex and its Interaction with DNA

A new complex of bis(N-benzyl benzotriazole-N3) dichloro Co(Ⅱ) (Co(Ⅱ)L2Cl2) was synthesized and its crystal was characterized. The interaction of this new complex with fs-DNA was studied by electrochemical and UV spectrophotometric method. In 0.01 mol/L pH 4.2Tris-HCl buffer solution Co(Ⅱ)L2Cl2 has two reductive peaks with peak potentials at 0.38 V and0.27 V, respectively, and an oxidative peak at 1.05 V. After the addition of DNA, the peak currents decrease and the peak potential at 0.27 V shifts negatively. The UV spectrophotometric experiment indicates that the maximum absorbance of Co(Ⅱ)L2Cl2 at 204 nm decreases and exhibits bathochromic shift after the addition of DNA. All the results reveal that Co(Ⅱ)L2Cl2binds with DNA by intercalation as well as electrostatic interaction.

作 者： Kui JIAO Qing Xiang WANG Wei SUN Fang Fang JIAN   作者单位： College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology. Qingdao 266042  刊 名： 中国化学快报（英文版）  ISTIC SCI 英文刊名： CHINESE CHEMICAL LETTERS  年，卷(期)： 2005 16(4)  分类号：   关键词： Cobalt complex   DNA   interaction   electrochemistry  

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