Improved Preparation of Tyramine by

Improved Preparation of Tyramine by Curtius Rearrangement

An improved and facile preparation of tyramine [2-(p-hydroxyphenyl)ethylamine] was described, which starts from phenol and acrylonitrile to form β-(p-hydroxyphenyl) propionic acid via Friedel-Craft's alkylation and nitrile hydrolysis. After hydrazinolysis and a subsequent Curtius rearrangement, tyramine was obtained in 30.2% total yield.

作 者： LI Yun YANG Fan XU Xiaoying PAN Shiyin WANG Lixin XIA Chuanqin   作者单位： LI Yun,YANG Fan,XIA Chuanqin(Department of Chemistry,Sichuan University,Chengdu,Sichuan 610041,China)

XU Xiaoying,PAN Shiyin,WANG Lixin(Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and National Engineering Research Center of Chiral Drugs,Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China) 

刊 名： 中国化学（英文版）  SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY  年，卷(期)： 2009 27(2)  分类号： O6  关键词： preparation   tyramine   β-(p-hydroxyphenyl)propionic acid   curtius rearrangement  

【Improved Preparation of Tyramine by 】相关文章：

Preparation of TiO2-activated carbon complex membranes and their photoelectrocatalytic activity04-27

Preparation and Characterization of Refuse Derived Fuel for Pyrolysis and Gasification by Bindless High Pressure Briquet04-26

Preparation and characterization of mixed hydroxy-Fe-Al pillared montmorillonite with large basal spacing04-26

Preparation and mechanism of Fe3O4/Au core/shell super-paramagnetic microspheres04-26