Expression and role of Tie-2 in rect

Expression and role of Tie-2 in rectal carcinoma

Objective To investigate the expression of Tie-2 in rectal carcinoma and its relationship with invasion and metastasis in rectal carcinoma. Materials S-P immunohistochemical assay was used to detect the expression of Tie-2 in 40 cases of rectal carcinoma and 10 cases of normal rectal tissues. Results Tie-2 was mainly localized in the cytoplasm and nucleus of vascular endothelial cells in cancerous tissues and partly in the cytoplasm of some cancerous cells. The expression of Tie-2 in rectal carcinoma was significantly higher than that in normal rectal tissues (P<0.05); however, Tie-2 expression was not associated with differentiation, invasion depth and Dukes stage (P>0.05), but with lymphatic metastasis (P<0.05). Conclusion Tie-2 plays a key role in carcinogenesis and lymph node metastasis of rectal carcinoma.

作 者： Zhen-Hua Ma Kang Wang Mao Zhang Wei-Hua Shang   作者单位： Department of General Surgery, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710061, China  刊 名： 西安交通大学学报（英文版）  英文刊名： ACADEMIC JOURNAL OF XI'AN JIAOTONG UNIVERSITY(ENGLISH EDITION)  年，卷(期)： 2010 22(1)  分类号： U4  关键词： Tie-2   rectal carcinoma   immunohistochemistry  

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